SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase

[Image: see text] The SAR of 4-hydroxybenzaldehyde inhibitors of the trypanosome alternative oxidase (TAO), a critical enzyme for the respiration of bloodstream forms of trypanosomes, was investigated. Replacing the aldehyde group with a methyl ester resulted in a 10-fold increase in TAO inhibition...

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Publicat a:ACS Med Chem Lett
Autors principals: Meco-Navas, Alejandro, Ebiloma, Godwin U., Martín-Domínguez, Ana, Martínez-Benayas, Irene, Cueto-Díaz, Eduardo J., Alhejely, Amani Saud, Balogun, Emmanuel O., Saito, Machi, Matsui, Miho, Arai, Natsumi, Shiba, Tomoo, Harada, Shigeharu, de Koning, Harry P., Dardonville, Christophe
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142067/
https://ncbi.nlm.nih.gov/pubmed/30258542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00282
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