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Ribosome-Templated Azide–Alkyne Cycloadditions Using Resistant Bacteria as Reaction Vessels: in Cellulo Click Chemistry
[Image: see text] In situ click chemistry has been a powerful method for fragment-based drug design since its discovery in 2002. Recently, we demonstrated that the bacterial ribosome can template the azide–alkyne cycloaddition reaction to expedite the discovery of novel antibiotics. We now report th...
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| Gepubliceerd in: | ACS Med Chem Lett |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2018
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6142060/ https://ncbi.nlm.nih.gov/pubmed/30258539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00248 |
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