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Precision DNA demethylation ameliorates disease in lupus-prone mice
Defective DNA methylation in T cells leads to a series of T cell abnormalities in lupus; however, the full effect of T cell lineage–specific DNA methylation on disease expression has not been explored. Here, we show that 5-azacytidine, a DNA methyltransferase inhibitor, targeted to either CD4 or CD8...
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| Wydane w: | JCI Insight |
|---|---|
| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6141184/ https://ncbi.nlm.nih.gov/pubmed/30135300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120880 |
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