The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia. During myocardial ischemia, p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then transphosphorylates TAB1. Previously, we solved the X-ray structure of the p38α-TAB1 (resi...

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Vydáno v:JCI Insight
Hlavní autoři: De Nicola, Gian F., Bassi, Rekha, Nichols, Charlie, Fernandez-Caggiano, Mariana, Golforoush, Pelin Arabacilar, Thapa, Dibesh, Anderson, Rhys, Martin, Eva Denise, Verma, Sharwari, Kleinjung, Jens, Laing, Adam, Hutchinson, Jonathan P., Eaton, Philip, Clark, James, Marber, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141180/
https://ncbi.nlm.nih.gov/pubmed/30135318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121144
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