Wilms’ tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease

Wilms’ tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during lung development but is downregulated in postnatal stages and adult lungs. We recently showed that WT1 is upregulated in both mesothelial cells and mesenchymal cells in the pathogenesis of idiopathic pulmonary f...

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Pubblicato in:JCI Insight
Autori principali: Sontake, Vishwaraj, Kasam, Rajesh K., Sinner, Debora, Korfhagen, Thomas R., Reddy, Geereddy B., White, Eric S., Jegga, Anil G., Madala, Satish K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141179/
https://ncbi.nlm.nih.gov/pubmed/30135315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121252
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