Wilms’ tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease

Wilms’ tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during lung development but is downregulated in postnatal stages and adult lungs. We recently showed that WT1 is upregulated in both mesothelial cells and mesenchymal cells in the pathogenesis of idiopathic pulmonary f...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Sontake, Vishwaraj, Kasam, Rajesh K., Sinner, Debora, Korfhagen, Thomas R., Reddy, Geereddy B., White, Eric S., Jegga, Anil G., Madala, Satish K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141179/
https://ncbi.nlm.nih.gov/pubmed/30135315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121252
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