Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era

ASXL1 (additional sex combs like 1) is a gene that is mutated in a number of hematological neoplasms. The most common genetic alteration is c.1934dupG p.Gly646fs. Previous publications have shown that ASXL1 mutations have a negative prognostic impact in patients with MDS and AML, however, controvers...

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Veröffentlicht in:PLoS One
Hauptverfasser: Montes-Moreno, Santiago, Routbort, Mark J., Lohman, Elijah J., Barkoh, Bedia A., Kanagal-Shamanna, Rashmi, Bueso-Ramos, Carlos E., Singh, Rajesh R., Medeiros, L. Jeffrey, Luthra, Raja, Patel, Keyur P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141087/
https://ncbi.nlm.nih.gov/pubmed/30222780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204218
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