H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

PD-1 is a co-repressive receptor that curbs T cell activation and thereby serves as a protection mechanism against autoimmunity under physiological conditions. Under pathological conditions, tumor cells express PD-L1 as an adaptive resistant mechanism to suppress PD-1(+) T cells to evade host immuno...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Redd, Priscilla S., Lu, Chunwan, Klement, John D., Ibrahim, Mohammed L., Zhou, Gang, Kumai, Takumi, Celis, Esteban, Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140591/
https://ncbi.nlm.nih.gov/pubmed/30228953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1483302
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