Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition

Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report the crystal structure of an antibody employing both modes of interaction simult...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mitropoulou, Alkistis N., Bowen, Holly, Dodev, Tihomir S., Davies, Anna M., Bax, Heather J., Beavil, Rebecca L., Beavil, Andrew J., Gould, Hannah J., James, Louisa K., Sutton, Brian J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140506/
https://ncbi.nlm.nih.gov/pubmed/30150373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806840115
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