Telomere shortening is a hallmark of genetic cardiomyopathies

This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Chang, Alex C. Y., Chang, Andrew C. H., Kirillova, Anna, Sasagawa, Koki, Su, Willis, Weber, Gerhard, Lin, Jue, Termglinchan, Vittavat, Karakikes, Ioannis, Seeger, Timon, Dainis, Alexandra M., Hinson, John T., Seidman, Jonathan, Seidman, Christine E., Day, John W., Ashley, Euan, Wu, Joseph C., Blau, Helen M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140486/
https://ncbi.nlm.nih.gov/pubmed/30150400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714538115
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