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Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

Duchenne muscular dystrophy (DMD) is an incurable X-linked genetic disease that is caused by a mutation in the dystrophin gene and affects one in every 3,600 boys. We previously showed that long telomeres protect mice from the lethal cardiac disease seen in humans with the same genetic defect, dystr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chang, Alex Chia Yu, Ong, Sang-Ging, LaGory, Edward L., Kraft, Peggy E., Giaccia, Amato J., Wu, Joseph C., Blau, Helen M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135315/
https://ncbi.nlm.nih.gov/pubmed/27799523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615340113
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