Telomere shortening is a hallmark of genetic cardiomyopathies

This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chang, Alex C. Y., Chang, Andrew C. H., Kirillova, Anna, Sasagawa, Koki, Su, Willis, Weber, Gerhard, Lin, Jue, Termglinchan, Vittavat, Karakikes, Ioannis, Seeger, Timon, Dainis, Alexandra M., Hinson, John T., Seidman, Jonathan, Seidman, Christine E., Day, John W., Ashley, Euan, Wu, Joseph C., Blau, Helen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140486/
https://ncbi.nlm.nih.gov/pubmed/30150400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714538115
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