Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers

Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a negative immune regulator on the surface of T cells. In humans, heterozygous germline mutations in CTLA4 can cause an immune dysregulation syndrome. The phenotype comprises a broad spectrum of autoinflammatory, autoimmune, and imm...

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Publicado no:Front Immunol
Main Authors: Egg, David, Schwab, Charlotte, Gabrysch, Annemarie, Arkwright, Peter D., Cheesman, Edmund, Giulino-Roth, Lisa, Neth, Olaf, Snapper, Scott, Okada, Satoshi, Moutschen, Michel, Delvenne, Philippe, Pecher, Ann-Christin, Wolff, Daniel, Kim, Yae-Jean, Seneviratne, Suranjith, Kim, Kyoung-Mee, Kang, Ji-Man, Ojaimi, Samar, McLean, Catriona, Warnatz, Klaus, Seidl, Maximilian, Grimbacher, Bodo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140401/
https://ncbi.nlm.nih.gov/pubmed/30250467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02012
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