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Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency
Autotaxin (ATX) is a secreted glycoprotein and the only member of the ectonucleotide pyrophosphatase/phosphodiesterase family that converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA controls key responses, such as cell migration, proliferation, and survival, implicating ATX...
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| Izdano u: | J Biol Chem |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6139564/ https://ncbi.nlm.nih.gov/pubmed/30026231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004450 |
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