Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones

Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side compartment of the growth cone that promotes F-act...

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Bibliografiske detaljer
Udgivet i:Front Cell Neurosci
Main Authors: Leung, Kin-Mei, Lu, Bo, Wong, Hovy Ho-Wai, Lin, Julie Qiaojin, Turner-Bridger, Benita, Holt, Christine E.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139529/
https://ncbi.nlm.nih.gov/pubmed/30250426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00300
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