Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones

Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side compartment of the growth cone that promotes F-act...

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Опубликовано в: :Front Cell Neurosci
Главные авторы: Leung, Kin-Mei, Lu, Bo, Wong, Hovy Ho-Wai, Lin, Julie Qiaojin, Turner-Bridger, Benita, Holt, Christine E.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Neuroscience
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139529/
https://ncbi.nlm.nih.gov/pubmed/30250426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00300
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