Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin

The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules in mice and whether...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Am J Physiol Renal Physiol
Päätekijät: Fu, Yiling, Breljak, Davorka, Onishi, Akira, Batz, Falk, Patel, Rohit, Huang, Winnie, Song, Panai, Freeman, Brent, Mayoux, Eric, Koepsell, Hermann, Anzai, Naohiko, Nigam, Sanjay K., Sabolic, Ivan, Vallon, Volker
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139528/
https://ncbi.nlm.nih.gov/pubmed/29412698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00503.2017
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