Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin

The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules in mice and whether...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Fu, Yiling, Breljak, Davorka, Onishi, Akira, Batz, Falk, Patel, Rohit, Huang, Winnie, Song, Panai, Freeman, Brent, Mayoux, Eric, Koepsell, Hermann, Anzai, Naohiko, Nigam, Sanjay K., Sabolic, Ivan, Vallon, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139528/
https://ncbi.nlm.nih.gov/pubmed/29412698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00503.2017
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