Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin

The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules in mice and whether...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Renal Physiol
Huvudupphovsmän: Fu, Yiling, Breljak, Davorka, Onishi, Akira, Batz, Falk, Patel, Rohit, Huang, Winnie, Song, Panai, Freeman, Brent, Mayoux, Eric, Koepsell, Hermann, Anzai, Naohiko, Nigam, Sanjay K., Sabolic, Ivan, Vallon, Volker
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139528/
https://ncbi.nlm.nih.gov/pubmed/29412698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00503.2017
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