Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin

The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules in mice and whether...

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書目詳細資料
發表在:Am J Physiol Renal Physiol
Main Authors: Fu, Yiling, Breljak, Davorka, Onishi, Akira, Batz, Falk, Patel, Rohit, Huang, Winnie, Song, Panai, Freeman, Brent, Mayoux, Eric, Koepsell, Hermann, Anzai, Naohiko, Nigam, Sanjay K., Sabolic, Ivan, Vallon, Volker
格式: Artigo
語言:Inglês
出版: American Physiological Society 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139528/
https://ncbi.nlm.nih.gov/pubmed/29412698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00503.2017
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