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VEGF-A selectively inhibits FLT1 ectodomain shedding independent of receptor activation and receptor endocytosis
Ectodomain shedding and regulated intracellular proteolysis can determine the fate or function of cell surface proteins. Fms-related tyrosine kinase (FLT) or VEGF receptor 1 is a high-affinity cell surface VEGF-A receptor tyrosine kinase that is constitutively cleaved to release an NH(2)-terminal VE...
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| Published in: | Am J Physiol Cell Physiol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Physiological Society
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6139503/ https://ncbi.nlm.nih.gov/pubmed/29719170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00247.2017 |
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