Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a canonical regulator of cytoprotective gene expression, but evidence of its cross talk with other pathways, including metabolic ones, is ever increasing. Pharmacologic or systemic genetic activation of the Nrf2 pathway partially protects from ob...

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Vydáno v:Am J Physiol Endocrinol Metab
Hlavní autoři: Chartoumpekis, Dionysios V., Palliyaguru, Dushani L., Wakabayashi, Nobunao, Fazzari, Marco, Khoo, Nicholas K. H., Schopfer, Francisco J., Sipula, Ian, Yagishita, Yoko, Michalopoulos, George K., O’Doherty, Robert M, Kensler, Thomas W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139497/
https://ncbi.nlm.nih.gov/pubmed/29486138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00311.2017
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