Inhibition of HER2 Increases Jagged1-dependent Breast Cancer Stem Cells: Role for Membrane Jagged1

PURPOSE: Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as Cancer Stem Cells (CSCs). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. Notch p...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Shah, Deep, Wyatt, Debra, Baker, Andrew T., Simms, Patricia, Peiffer, Daniel S., Fernandez, Michelle, Rakha, Emad, Green, Andrew, Filipovic, Alexandra, Miele, Lucio, Osipo, Clodia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139046/
https://ncbi.nlm.nih.gov/pubmed/29895705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1952
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