PKCα Attenuates Jagged-1-mediated Notch Signaling in ErbB-2 positive Breast Cancer to Reverse Trastuzumab Resistance

PURPOSE: Breast cancer is the second leading cause of cancer mortality among women worldwide. The major problem with current treatments is tumor resistance, recurrence, and disease progression. ErbB-2 positive breast tumors are aggressive and frequently become resistant to trastuzumab or lapatinib....

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Pandya, Kinnari, Wyatt, Debra, Gallagher, Brian, Shah, Deep, Baker, Andrew, Bloodworth, Jeffrey, Zlobin, Andrei, Pannuti, Antonio, Green, Andrew, Ellis, Ian O., Filipovic, Aleksandra, Sagert, Jason, Rana, Ajay, Albain, Kathy S., Miele, Lucio, Denning, Mitchell F., Osipo, Clodia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703529/
https://ncbi.nlm.nih.gov/pubmed/26350262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0179
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