Trastuzumab Resistance: Role for Notch Signaling

Epidermal growth factor receptor-2 (ErbB-2/HER2) is a potent breast oncogene that has been shown to be amplified in 20% of breast cancers. Overexpression of ErbB-2 predicts for aggressive tumor behavior, resistance to some cytotoxic and antihormonal therapies, and poor overall survival. Trastuzumab,...

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Bibliographic Details
Published in:ScientificWorldJournal
Main Authors: Mehta, Kinnari, Osipo, Clodia
Format: Artigo
Language:Inglês
Published: TheScientificWorldJOURNAL 2009
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823123/
https://ncbi.nlm.nih.gov/pubmed/20024517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/tsw.2009.166
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