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A novel diindolylmethane analog, 1,1-bis(3′-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism

The progression of rheumatoid arthritis involves the thickening of the synovial lining due to the proliferation of fibroblast-like synoviocytes (FLS) and infiltration by inflammatory cells. Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine involved in progression of the disease. Unde...

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Udgivet i:Mol Immunol
Main Authors: Afzali, Maryam F., Popichak, Katriana A., Burton, Lindsey H., Klochak, Anna L., Wilson, William J, Safe, Stephen, Tjalkens, Ronald B., Legare, Marie E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138555/
https://ncbi.nlm.nih.gov/pubmed/29870816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2018.05.024
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