TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying molecular mechanisms controlling the turnover of protein aggregates are mostly uncharacterized. Herein, we show that a TRIM fami...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Jena, Kautilya Kumar, Kolapalli, Srinivasa Prasad, Mehto, Subhash, Nath, Parej, Das, Biswajit, Sahoo, Pradyumna Kumar, Ahad, Abdul, Syed, Gulam Hussain, Raghav, Sunil K, Senapati, Shantibhusan, Chauhan, Swati, Chauhan, Santosh
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138442/
https://ncbi.nlm.nih.gov/pubmed/30143514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798358
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