TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying molecular mechanisms controlling the turnover of protein aggregates are mostly uncharacterized. Herein, we show that a TRIM fami...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Jena, Kautilya Kumar, Kolapalli, Srinivasa Prasad, Mehto, Subhash, Nath, Parej, Das, Biswajit, Sahoo, Pradyumna Kumar, Ahad, Abdul, Syed, Gulam Hussain, Raghav, Sunil K, Senapati, Shantibhusan, Chauhan, Swati, Chauhan, Santosh
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138442/
https://ncbi.nlm.nih.gov/pubmed/30143514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798358
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