IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy

IRGM is an established genetic risk factor for Crohn disease (CD) and several other inflammatory disorders. However, the mechanisms employed by IRGM to restrain the inflammation are not known. In our recent study, we showed that IRGM negatively regulates NLRP3 inflammasome activation. IRGM employs 2...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Mehto, Subhash, Chauhan, Swati, Jena, Kautilya Kumar, Chauhan, Nishant Ranjan, Nath, Parej, Sahu, Rinku, Dhar, Kollori, Das, Saroj Kumar, Chauhan, Santosh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Commentary
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693461/
https://ncbi.nlm.nih.gov/pubmed/31177914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1628544
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