IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy

IRGM is an established genetic risk factor for Crohn disease (CD) and several other inflammatory disorders. However, the mechanisms employed by IRGM to restrain the inflammation are not known. In our recent study, we showed that IRGM negatively regulates NLRP3 inflammasome activation. IRGM employs 2...

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發表在:Autophagy
Main Authors: Mehto, Subhash, Chauhan, Swati, Jena, Kautilya Kumar, Chauhan, Nishant Ranjan, Nath, Parej, Sahu, Rinku, Dhar, Kollori, Das, Saroj Kumar, Chauhan, Santosh
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2019
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Commentary
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693461/
https://ncbi.nlm.nih.gov/pubmed/31177914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1628544
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