IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy

IRGM is an established genetic risk factor for Crohn disease (CD) and several other inflammatory disorders. However, the mechanisms employed by IRGM to restrain the inflammation are not known. In our recent study, we showed that IRGM negatively regulates NLRP3 inflammasome activation. IRGM employs 2...

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Detalles Bibliográficos
Publicado en:Autophagy
Main Authors: Mehto, Subhash, Chauhan, Swati, Jena, Kautilya Kumar, Chauhan, Nishant Ranjan, Nath, Parej, Sahu, Rinku, Dhar, Kollori, Das, Saroj Kumar, Chauhan, Santosh
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2019
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Commentary
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693461/
https://ncbi.nlm.nih.gov/pubmed/31177914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1628544
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