Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response

Activation of the type 1 interferon response is extensively connected to the pathogenesis of autoimmune diseases. Loss of function of Immunity Related GTPase M (IRGM) has also been associated to several autoimmune diseases, but its mechanism of action is unknown. Here, we found that IRGM is a master...

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Udgivet i:EMBO Rep
Main Authors: Jena, Kautilya Kumar, Mehto, Subhash, Nath, Parej, Chauhan, Nishant Ranjan, Sahu, Rinku, Dhar, Kollori, Das, Saroj Kumar, Kolapalli, Srinivasa Prasad, Murmu, Krushna C, Jain, Ashish, Krishna, Sivaram, Sahoo, Bhabani Sankar, Chattopadhyay, Soma, Rusten, Tor Erik, Prasad, Punit, Chauhan, Swati, Chauhan, Santosh
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507369/
https://ncbi.nlm.nih.gov/pubmed/32715615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050051
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