ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair processes at stalled or converging replication forks. Recent...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Mutreja, Karun, Krietsch, Jana, Hess, Jeannine, Ursich, Sebastian, Berti, Matteo, Roessler, Fabienne K., Zellweger, Ralph, Patra, Malay, Gasser, Gilles, Lopes, Massimo
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137818/
https://ncbi.nlm.nih.gov/pubmed/30184498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.019
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