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ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair processes at stalled or converging replication forks. Recent...

詳細記述

保存先:
書誌詳細
出版年:Cell Rep
主要な著者: Mutreja, Karun, Krietsch, Jana, Hess, Jeannine, Ursich, Sebastian, Berti, Matteo, Roessler, Fabienne K., Zellweger, Ralph, Patra, Malay, Gasser, Gilles, Lopes, Massimo
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137818/
https://ncbi.nlm.nih.gov/pubmed/30184498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.019
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