Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

Sepsis—leading to septic shock—is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role in the lethal outcome. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory m...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Sparkes, Amanda, De Baetselier, Patrick, Brys, Lea, Cabrito, Inês, Sterckx, Yann G.-J., Schoonooghe, Steve, Muyldermans, Serge, Raes, Geert, Bucala, Richard, Vanlandschoot, Peter, Van Ginderachter, Jo A., Stijlemans, Benoît
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137717/
https://ncbi.nlm.nih.gov/pubmed/29401625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701189R
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