Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

Sepsis—leading to septic shock—is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role in the lethal outcome. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory m...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Sparkes, Amanda, De Baetselier, Patrick, Brys, Lea, Cabrito, Inês, Sterckx, Yann G.-J., Schoonooghe, Steve, Muyldermans, Serge, Raes, Geert, Bucala, Richard, Vanlandschoot, Peter, Van Ginderachter, Jo A., Stijlemans, Benoît
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137717/
https://ncbi.nlm.nih.gov/pubmed/29401625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701189R
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