Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

Sepsis—leading to septic shock—is the leading cause of death in intensive care units. The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role in the lethal outcome. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory m...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Sparkes, Amanda, De Baetselier, Patrick, Brys, Lea, Cabrito, Inês, Sterckx, Yann G.-J., Schoonooghe, Steve, Muyldermans, Serge, Raes, Geert, Bucala, Richard, Vanlandschoot, Peter, Van Ginderachter, Jo A., Stijlemans, Benoît
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137717/
https://ncbi.nlm.nih.gov/pubmed/29401625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701189R
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