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Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region

Soluble Aβ oligomers (oAβs) contribute importantly to synaptotoxicity in Alzheimer disease (AD), but the mechanisms related to heterogeneity of synaptic functions at local circuits remain elusive. Nearly all studies of the effects of oAβs on hippocampal synaptic plasticity have only examined homosyn...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Zhao, Jianhua, Li, Anna, Rajsombath, Molly, Dang, Yifan, Selkoe, Dennis J., Li, Shaomin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137707/
https://ncbi.nlm.nih.gov/pubmed/30240608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.07.018
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