Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its mitochondrial accumulation; this dramatically increases its potency and efficacy against highly metastatic lung cancer lines in vitro, and in orthotopic lung tumor xenografts and brain metastases in vivo. Mito-HNK is >...

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Bibliografski detalji
Izdano u:iScience
Glavni autori: Pan, Jing, Lee, Yongik, Cheng, Gang, Zielonka, Jacek, Zhang, Qi, Bajzikova, Martina, Xiong, Donghai, Tsaih, Shirng-Wern, Hardy, Micael, Flister, Michael, Olsen, Christopher M., Wang, Yian, Vang, Ole, Neuzil, Jiri, Myers, Charles R., Kalyanaraman, Balaraman, You, Ming
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137433/
https://ncbi.nlm.nih.gov/pubmed/30428319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.04.013
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