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Hydropropidine: A novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide

Here we report the synthesis and characterization of a membrane-impermeant fluorogenic probe, hydropropidine (HPr(+)), the reduction product of propidium iodide, for detecting extracellular superoxide (O(2)(·−)). HPr(+) is a positively-charged water-soluble analog of hydroethidine (HE), a fluorogeni...

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Detalhes bibliográficos
Main Authors: Michalski, Radoslaw, Zielonka, Jacek, Hardy, Micael, Joseph, Joy, Kalyanaraman, Balaraman
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711142/
https://ncbi.nlm.nih.gov/pubmed/23051008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.09.018
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