Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide

Hydroethidine (HE) and hydropropidine ([Formula: see text] ) are fluorogenic probes used for the detection of the intra- and extracellular superoxide radical anion ([Formula: see text] ). In this study, we provide evidence that HE and [Formula: see text] react rapidly with the biologically relevant...

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Udgivet i:Sci Rep
Main Authors: Michalski, Radosław, Thiebaut, David, Michałowski, Bartosz, Ayhan, Mehmet M., Hardy, Micael, Ouari, Olivier, Rostkowski, Michał, Smulik-Izydorczyk, Renata, Artelska, Angelika, Marcinek, Andrzej, Zielonka, Jacek, Kalyanaraman, Balaraman, Sikora, Adam
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596101/
https://ncbi.nlm.nih.gov/pubmed/33122809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75373-2
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