Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the Mitochondrial Pyruvate Carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferati...

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Publicado no:Nat Cell Biol
Main Authors: Schell, John C., Wisidagama, Dona R., Bensard, Claire, Zhao, Helong, Wei, Peng, Tanner, Jason, Flores, Aimee, Mohlman, Jeffrey, Sorensen, Lise K., Earl, Christian S., Olson, Kristofor A., Miao, Ren, Waller, T. Cameron, Delker, Don, Kanth, Priyanka, Jiang, Lei, DeBerardinis, Ralph J., Bronner, Mary P., Li, Dean Y., Cox, James E., Christofk, Heather R., Lowry, William E., Thummel, Carl S., Rutter, Jared
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137334/
https://ncbi.nlm.nih.gov/pubmed/28812582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3593
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