SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-ret...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: McGough, Ian J., de Groot, Reinoud E. A., Jellett, Adam P., Betist, Marco C., Varandas, Katherine C., Danson, Chris M., Heesom, Kate J., Korswagen, Hendrik C., Cullen, Peter J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137200/
https://ncbi.nlm.nih.gov/pubmed/30213940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06114-3
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