Active N(6)-Methyladenine demethylation by DMAD regulates gene expression by coordinating with Polycomb protein in neurons

A Ten-Eleven Translocation (TET) ortholog exists as a DNA N(6)-Methyladenine (6mA) demethylase (DMAD) in Drosophila. However, the molecular roles of 6mA and DMAD remain unexplored. Through genome-wide 6mA and transcriptome profiling in Drosophila brains and neuronal cells, we found that 6mA may epig...

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Pubblicato in:Mol Cell
Autori principali: Yao, Bing, Li, Yujing, Wang, Zhiqin, Chen, Li, Poidevin, Mickael, Zhang, Can, Lin, Li, Wang, Feng, Bao, Han, Jiao, Bin, Lim, Junghwa, Cheng, Ying, Huang, Luoxiu, Phillips, Brittany Lynn, Xu, Tianlei, Duan, Ranhui, Moberg, Kenneth H., Wu, Hao, Jin, Peng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136845/
https://ncbi.nlm.nih.gov/pubmed/30078725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.005
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