ALKBH1-demethylated DNA N(6)-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease

Vascular calcification (VC) predicts cardiovascular morbidity and mortality in chronic kidney disease (CKD). To date, the underlying mechanisms remain unclear. We detected leukocyte DNA N(6)-methyladenine (6mA) levels in patients with CKD with or without aortic arch calcification. We used arteries f...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Ouyang, Liu, Su, Xiaoyan, Li, Wenxin, Tang, Liangqiu, Zhang, Mengbi, Zhu, Yongjun, Xie, Changming, Zhang, Puhua, Chen, Jie, Huang, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279589/
https://ncbi.nlm.nih.gov/pubmed/34003800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146985
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