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An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing
Adenine N6 methylation in DNA (6mA) is widespread among bacteria and phage and is detected in mammalian genomes, where its function is largely unexplored. Here we show that 6mA deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA acc...
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| I publikationen: | Mol Cell |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Cell Press
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591016/ https://ncbi.nlm.nih.gov/pubmed/30982744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.018 |
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