An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing

Adenine N6 methylation in DNA (6mA) is widespread among bacteria and phage and is detected in mammalian genomes, where its function is largely unexplored. Here we show that 6mA deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA acc...

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Udgivet i:Mol Cell
Main Authors: Kweon, Soo-Mi, Chen, Yibu, Moon, Eugene, Kvederaviciutė, Kotryna, Klimasauskas, Saulius, Feldman, Douglas E.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591016/
https://ncbi.nlm.nih.gov/pubmed/30982744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.018
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