Behavioral Effect of Chemogenetic Inhibition Is Directly Related to Receptor Transduction Levels in Rhesus Monkeys

We used inhibitory DREADDs (designer receptors exclusively activated by designer drugs) to reversibly disrupt dorsolateral prefrontal cortex (dlPFC) function in male rhesus monkeys. Monkeys were tested on a spatial delayed response task to assess working memory function after intramuscular injection...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Upright, Nicholas A., Brookshire, Stephen W., Schnebelen, Wendy, Damatac, Christienne G., Hof, Patrick R., Browning, Philip G.F., Croxson, Paula L., Rudebeck, Peter H., Baxter, Mark G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136156/
https://ncbi.nlm.nih.gov/pubmed/30082415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1422-18.2018
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