Behavioral Effect of Chemogenetic Inhibition Is Directly Related to Receptor Transduction Levels in Rhesus Monkeys

We used inhibitory DREADDs (designer receptors exclusively activated by designer drugs) to reversibly disrupt dorsolateral prefrontal cortex (dlPFC) function in male rhesus monkeys. Monkeys were tested on a spatial delayed response task to assess working memory function after intramuscular injection...

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Библиографические подробности
Опубликовано в: :J Neurosci
Главные авторы: Upright, Nicholas A., Brookshire, Stephen W., Schnebelen, Wendy, Damatac, Christienne G., Hof, Patrick R., Browning, Philip G.F., Croxson, Paula L., Rudebeck, Peter H., Baxter, Mark G.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136156/
https://ncbi.nlm.nih.gov/pubmed/30082415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1422-18.2018
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