Behavioral Effect of Chemogenetic Inhibition Is Directly Related to Receptor Transduction Levels in Rhesus Monkeys

We used inhibitory DREADDs (designer receptors exclusively activated by designer drugs) to reversibly disrupt dorsolateral prefrontal cortex (dlPFC) function in male rhesus monkeys. Monkeys were tested on a spatial delayed response task to assess working memory function after intramuscular injection...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Upright, Nicholas A., Brookshire, Stephen W., Schnebelen, Wendy, Damatac, Christienne G., Hof, Patrick R., Browning, Philip G.F., Croxson, Paula L., Rudebeck, Peter H., Baxter, Mark G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136156/
https://ncbi.nlm.nih.gov/pubmed/30082415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1422-18.2018
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