Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity

The tissue inhibitor of metalloproteinases 2 (TIMP-2) is a specific endogenous inhibitor of matrix metalloproteinase 2 (MMP-2), which is a key enzyme that degrades the extracellular matrix and promotes tumor cell invasion. Although the TIMP-2:MMP-2 complex controls proteolysis, the signaling mechani...

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Pubblicato in:iScience
Autori principali: Sánchez-Pozo, Javier, Baker-Williams, Alexander J., Woodford, Mark R., Bullard, Renee, Wei, Beiyang, Mollapour, Mehdi, Stetler-Stevenson, William G., Bratslavsky, Gennady, Bourboulia, Dimitra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135941/
https://ncbi.nlm.nih.gov/pubmed/30227959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.02.004
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