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TIMP-2 targets tumor associated-myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis

Angiogenesis and inflammation are important therapeutic targets in non-small cell lung cancer (NSCLC). It is well known that proteolysis mediated by matrix metalloproteinases (MMPs) promotes angiogenesis and inflammation in the tumor microenvironment. Here, the effects of the MMP-inhibitor TIMP-2 on...

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Autors principals: Guedez, Liliana, Jensen-Taubman, Sandra, Bourboulia, Dimitra, Kwityn, Clifford J, Wei, Beiyang, Caterina, John, Stetler-Stevenson, William G.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402087/
https://ncbi.nlm.nih.gov/pubmed/22735808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182619c8e
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