PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin

RHO GTPases regulate essential functions such as the organization of the actin cytoskeleton. The classic members cycle between an active GTP-bound and an inactive GDP-bound conformation whereas atypical members are predominantly GTP-bound. Besides their well-established role, the classic RHO GTPases...

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Publicat a:Cell Death Dis
Autors principals: Mouly, Laetitia, Mamouni, Kenza, Gence, Remi, Cristini, Agnese, Cherier, Julia, Castinel, Adrien, Legrand, Morgane, Favre, Gilles, Sordet, Olivier, Monferran, Sylvie
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135836/
https://ncbi.nlm.nih.gov/pubmed/30209297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0981-3
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